Whether you're auditioning from a P2P audition site, through your agent or just a random VO buyer who wants to hear a few reads before they hire you, it's vital to think out of the box and give yourself the best chance to book the gig.
When looking at the script, study the message and pay attention to who the target audience is. This will make a difference in how the script should be performed. For example, if it's a commercial aimed at teenagers, your performance will sound quite different than if the campaign is aimed at adults 45 and up.